Mitochondria, cholesterol and cancer cell metabolism
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چکیده
منابع مشابه
Mitochondria, cholesterol and cancer cell metabolism
Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progression of cancer. Cancer cells exhibit an array of metabolic transformations induced by mutations leading to gain-of-function of oncogenes and loss-of-function of tumor suppressor genes that i...
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Background It is well known that physical or chemical agents can induce cell differentiation, or better pseudo-differentiation, in different human tumor cell lines. As an example, we cite the synthetic ligands of Peroxisome Proliferators Activated Receptors (PPARs), a very heterogeneous class of chemical with numerous biological activities which are mainly reported for their capacity to bind an...
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Cancer is a disease characterized by uncontrolled growth. Metabolic demands to sustain rapid proliferation must be compelling since aerobic glycolysis is the first as well as the most commonly shared characteristic of cancer. During the last decade, the significance of metabolic reprogramming of cancer has been at the center of attention. Nonetheless, despite all the knowledge gained on cancer ...
متن کاملCrocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines
Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt/Cro on lipid content in breast cancer. Materials and M...
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As sites of cellular respiration and energy production, mitochondria play a central role in cell metabolism. Cell differentiation is associated with an increase in mitochondrial content and activity and with a metabolic shift toward increased oxidative phosphorylation activity. The opposite occurs during reprogramming of somatic cells into induced pluripotent stem cells. Studies have provided e...
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ژورنال
عنوان ژورنال: Clinical and Translational Medicine
سال: 2016
ISSN: 2001-1326,2001-1326
DOI: 10.1186/s40169-016-0106-5